It is not chordoma, so treatment is possible, go get a sample to test what it is

China Daily/Asia News Network
Wednesday, Jun 06, 2012

CHINA – Li Hongfang, of the remote Tianchao village in Qian county of Xianyang, Northwest China’s Shaanxi province, has seven tumors on her face that scare people away.
The nightmare started for the 40-year-old woman in 2001, when she noticed a fingernail-sized lump on her forehead. She ignored it as it was not itchy or painful. But its increasingly worrisome appearance finally became urgent, and Li sought help at an infirmary in the county, with 300 yuan (S$61) and two bags of wheat in hand.
The scans produced no results. The doctor suggested she go to a large hospital in Xi’an, capital city of the province, for further tests. Li refused because she feared a hefty cost, a decision that she regrets.
After enduring the pain for another four years, during which she lost her husband to a cerebral hemorrhage in 2005, Li sold all her valuables for several thousand yuan, to get surgery in Xi’an. But things did not turn out well.
The doctors, after another examination, diagnosed the seven facial tumors as chordoma, a kind of bone cancer, and it would cost at least 600,000 yuan for the surgery.
Li didn’t understand how big the sum was, but she knew such a number was way beyond what she could afford. She received no government subsidies because she did not participated in China’s rural cooperative medical care system.
The only other option she had was to see more doctors in big cities and try a variety of medicines, which meant she had to commute to Xianyang, 50 kilometers away, and Xi’an, 70 kilometers.
For a widow with two sons to raise, it was a huge hardship. Her savings soon ran out, and the debt-ridded Li sometimes could only beg on the streets for her treatment, which was 700 yuan at a time.
She gained some comfort from her second husband, Guo Yingping, by 2009, who shared her 10-square-meter shed. Guo makes a living by building houses in nearby villages, and he spends all his wages, about 80 yuan per day, on his wife’s treatment.
Her two sons, 17 and 14, left the village to work despite her objections.
But her tumors are getting worse, covering the entire right side of her face and growing down to her breast. She also lost much of her hair.
Li, in spite of all those setbacks, said she would stay positive.
“I don’t want my sons to lose their mother early like I did, so I have to be tough.”
She hopes her sons can go back to school after she is cured.
Several students from home and abroad visited Li in April and wrote about her on Weibo, China’s Twitter-like service, which was forwarded by thousands who sent text messages to encourage Li and called for help from the public.
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WASHINGTON: A newly approved drug has shown promise in keeping two rare variations of skin cancer at bay, according to research published in the New England Journal of Medicine on Wednesday.
The drug, Erivedge (vismodegib), is made by Genentech, a US subsidiary of the Swiss drug giant Roche, and was approved by the US Food and Drug Administration in January after an expedited review.
It aims to treat basal cell carcinoma, which is the most common form of skin cancer in the world but which is rarely deadly. Basal cell carcinoma accounts for 80 percent of non-melanoma cancers and some two million new cases in the US each year.
The journal published two studies that show how it helped some patients with two unusual variations of basal cell carcinoma: metastatic basal cell carcinoma and Gorlin syndrome, also known as Basal Cell Nevus Syndrome.
There is no other treatment for Gorlin syndrome, which strikes one in 50,000 people and involves the constant growth of tumours, which are often not deadly but can cause scarring and require frequent surgeries.
Subjects with Gorlin syndrome who took vismodegib developed an average of two new tumours per year, compared with 29 new tumours in subjects taking a placebo, the study said.
When it came to people whose basal cell carcinoma had spread, the study showed 30 percent of 33 patients with metastatic basal cell carcinoma responded to treatment, meaning their tumours shrank.
Forty-three percent of 63 subjects with locally advanced basal cell carcinoma responded in kind.
The phase II study showed a median progression-free survival time of 9.5 months, but overall survival rates have not yet been established.
“It is a landmark day for patients with basal cell carcinoma and all those involved in their care — the greatest advance in therapy yet seen for this disease,” said an accompanying editorial by John Lear, consultant dermatologist at Manchester Royal Infirmary in Britain.
However, he pointed out the high rate of adverse effects, including loss of taste, hair loss and muscle cramps, which led to a high rate of people dropping out of the study early.
“Side effects are considerable and frequent, resulting in high rates of drug discontinuation, and these rates will probably be even higher in clinical practice,” Lear said.
More study is needed to determine how long the drug may work to ward off cancer, what populations it may best serve, and when it should be optimally administered, he added.

– AFP/al

Author: Gilbert Tan TS

IT expert with more than 20 years experience in Apple, Andriod and Windows PC. Interests include hardware and software, Internet and multimedia. An experienced Real Estate agent, Insurance agent, and a Futures trader.

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